Summarized by Masters of Longevity from Frontiers - Health.
Knee osteoarthritis readers will find a narrative review exploring how exosomal microRNAs from various tissues may mediate disease biology and exercise-related muscle–joint signaling.
Key Takeaways
- Knee osteoarthritis (KOA) is the most prevalent degenerative joint disorder in the aging population and a leading cause of joint deformity and physical disability.
- Long-term KOA management demands sustained pharmacological and lifestyle interventions, while advanced stages often necessitate joint replacement surgery, imposing heavy socioeconomic burdens.
- This narrative review examines the roles of exosomal microRNAs (miRNAs) from diverse cellular sources in KOA, with particular emphasis on exercise-regulated, skeletal muscle-derived exosomal miRNAs.
