Summarized by Masters of Longevity from Fight Aging!.
Report on a study linking reduced mitochondrial cardiolipin to muscle fiber remodeling and functional decline, and on genetic restoration reversing those changes.
Key Takeaways
- Age-related decline in cardiolipin synthesis causally drove a shift from glycolytic to oxidative muscle fibers in mice.
- Cardiolipin loss triggered mitochondria-to-nucleus signaling via estrogen-related receptor gamma and altered glucose and antioxidant metabolism.
- Restoring cardiolipin synthase expression in knockout mice recovered cardiolipin levels, reversed muscle atrophy, and rescued premature mortality.
