Summarized by Masters of Longevity from Fight Aging!.
Therapeutic possibilities for delivering mitochondria are examined, offering a survey-style article on engineered delivery strategies and challenges.
Key Takeaways
- Free isolated mitochondria lose function rapidly outside cells because of mechanical stress and oxidative damage.
- Engineered delivery approaches include surface-engineered mitochondria, cell-mediated transport, and vesicle-encapsulated delivery.
- Therapeutic translation will require scalable, targetable systems that mimic protective features of endogenous mitochondrial transfer.
