Summarized by Masters of Longevity from Frontiers - Health.
Physical activity and wearable-measured behaviors are examined as repeatable research signals in studies of preclinical Alzheimer disease, with guidance for longitudinal multimodal designs aimed at linking behavior to biomarkers and cognitive trajectories.
Key Takeaways
- Objective wearable measures of physical activity, gait, and rest-activity are repeatable, inexpensive research signals but are not specific biomarkers for Alzheimer disease.
- Higher baseline step counts in biomarker-characterized cohorts have been associated with slower tau accumulation and slower cognitive and functional decline.
