News summary

Oral NLRP3 inhibitor ruvonoflast cut hsCRP 82% in 28-day phase 1b

Source: Longevity Docs News • Published: 31 Oct 2026, 00:00

Summarized by Masters of Longevity from Longevity Docs News.

Phase 1b trial found ruvonoflast lowered hsCRP 82% over 28 days versus 37% with placebo.

Oral NLRP3 inhibitor ruvonoflast cut hsCRP 82% in 28-day phase 1b
Key Takeaways
  • Ruvonoflast lowered hsCRP 82% in adults with obesity.
  • The trial was small, inpatient, and measured only a biomarker.
  • CRP rebound within a week showed continued dosing may be needed.
Read the full article at Longevity Docs News ↗

Continue exploring

Recommended MoL Picks

MoL PickThe Next Obesity-Drug Race Is About What Weight You LoseRegeneron’s myostatin and activin A antibodies point to a sharper question for the GLP-1 era: not whether people can lose more weight, but whether medicine can preserve the tissue that makes weight loss healthier.MoL PickSemaglutide Extended Lifespan in Mice. What Would Make It a Human Longevity Drug?A new animal study sharpens an important question: when do benefits in a particular disease become evidence for a longer, healthier life?MoL PickApoB: The cholesterol signal LDL can missIn longevity medicine, the useful biomarkers are not always the exotic ones. ApoB is a relatively simple blood test that can sharpen cardiovascular prevention when LDL-C looks reassuring but particle burden remains high.