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Nonlinear Aging of the Human TCR Repertoire Is Influenced by Sex, CMV, and Cancer

Source: Aging Cell • Published: 26 Oct 2026, 03:37

Summarized by Masters of Longevity from Aging Cell.

Researchers found nonlinear age-related changes in human T cell receptor repertoires influenced by sex, CMV, and cancer.

Nonlinear Aging of the Human TCR Repertoire Is Influenced by Sex, CMV, and Cancer
Key Takeaways
  • TCR diversity declines with age but the decline is nonlinear.
  • Sex is associated with different TCR aging trajectories.
  • CMV seropositivity and cancer history are linked to altered TCR aging.
Read the full article at Aging Cell ↗

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