Summarized by Masters of Longevity from Nature - Biotechnology.
Engineered nanobodies bind C5a and block its receptor activation in cell assays.
Key Takeaways
- Nanobodies are shown to bind human and mouse C5a with high affinity.
- In cell assays these nanobodies were reported to block receptor activation.
- Structural work showed the nanobody mimics a C5aR1 extracellular turn.
