Summarized by Masters of Longevity from Longevity Technology.
An oral TREM2 agonist moved elderly CSF markers toward younger patterns.
Key Takeaways
- MNA-001 reached the brain with dose-related CNS exposure.
- Soluble TREM2 in CSF and plasma fell with higher doses.
- Repeated dosing shifted elderly microglial and stress markers toward younger.
