Summarized by Masters of Longevity from Fight Aging!.
MiR-128-3p inhibition: a short feature on a preclinical therapeutic approach that aims to reverse age‑related muscle and heart decline, with implications for broader aging research.
Key Takeaways
- Antisense oligonucleotide inhibition of miR-128-3p restored muscle mass and improved function in aged mice.
- MiR-128-3p inhibition improved cardiac function and limited adverse remodeling after myocardial infarction in animal models.
- Inhibition activated mitochondrial programs and suppressed inflammatory and fibrotic signaling across mouse and pig models.
