Summarized by Masters of Longevity from Lifespan.io.
Reports that specific midlife serum protein changes linked to menopause map onto brain aging and predict later cognitive decline and dementia risk.
Key Takeaways
- The study identified 16 serum proteins that increase after menopause and relate to inflammatory, synaptic, metabolic, and Alzheimer’s processes.
- Higher baseline menopause proteomic scores correlated with worse cognitive outcomes and higher Alzheimer’s dementia risk in four independent older-woman cohorts.
- The menopause proteomic score was positively associated with FSH and inversely associated with estradiol, with no association to progesterone.
