Summarized by Masters of Longevity from Neuroscience News.
Sepsis-driven immune cell entry into the hippocampus and its long-term effects — a neuroscience feature exploring mechanisms and implications for memory decline.
Key Takeaways
- Bone marrow chimera tracing showed infiltrating CCR2+ macrophages persist in the hippocampus for at least six months post-sepsis.
- Macrophage-derived pleiotrophin engaged microglial CD11b, triggering microglial activation and excessive myelin engulfment.
- Natalizumab blockade of initial cellular infiltration prevented chronic memory deficits in the mouse sepsis model.
