Summarized by Masters of Longevity from Nature - Main.
A Drosophila adipose protein, induced by dietary essential amino acids, links mTORC1 activity to selective TOP mRNA translation and affects lifespan.
Key Takeaways
- Mechanistic target of rapamycin complex 1 (mTORC1) senses nutrient availability to orchestrate metabolic processes that are crucial for physiological homeostasis and ageing 1.
- MTORC1 preferentially regulates the translation of 5′-terminal oligopyrimidine (TOP) motif-containing mRNAs (which encode mainly ribosomal proteins) through the 4E-BP translational repressor 2 ; however, this function of mTORC1 is resistant to rapamycin inhibition 3.
- TOP mRNAs are exceptionally abundant, and thus impose a major translational burden on cells, but how their translation is physiologically tuned and linked with lifespan remains unclear.
