Summarized by Masters of Longevity from medRxiv.
Longitudinal MRI and perfusion changes were tracked in older adults with Mild Cognitive Impairment and linked to worsening neuropsychiatric symptoms over about 2.4 years.
Key Takeaways
- Total grey and white matter volumes declined significantly over a mean 29 month follow up period.
- Right parahippocampal gyrus volume loss was associated with increased aggression.
- Lower baseline right entorhinal cortex volume and lower right hippocampal and parahippocampal CBF predicted worsening agitation and aggression.
