Summarized by Masters of Longevity from Longevity Technology.
Reanalysis of a small Alzheimer’s trial suggests a mesenchymal stem cell therapy reduced MRI markers of brain inflammation and correlated with cognitive and biomarker changes.
Key Takeaways
- A post-hoc medRxiv preprint re-examined 49 CLEAR MIND trial participants and used free water MRI to assess neuroinflammation.
- Laromestrocel treatment showed statistically significant reductions in hippocampal free water with p<0.001 in both 25M and 100M dose groups.
- Treated participants had less brain atrophy, better MoCA cognitive scores, and lower plasma neurogranin compared with baseline observations.
