Summarized by Masters of Longevity from Nature - Main.
A lifespan single-cell atlas of the human prefrontal cortex — a research article guiding readers through cell-type–resolved developmental, midlife, and late‑life molecular program mapping.
Key Takeaways
- The dorsolateral prefrontal cortex shows non-linear, cell-type-specific transcriptional changes across the human lifespan.
- Development features dynamic neuronal remodeling and resilience programs, while midlife exhibits relative molecular stability.
- Late adulthood involves selective reactivation of glial programs linked to immune activation, stress responses, and circadian reorganization.
