Summarized by Masters of Longevity from Nature - Main.
Study shows serine-deficient pancreatic cancer cells reprogram nearby hepatocytes to upregulate serine synthesis, supporting liver metastatic growth and identifying intervention points.
Key Takeaways
- The liver is the primary site of metastasis in pancreatic ductal adenocarcinoma (PDAC), and liver metastases are a major cause of mortality 1 , 2.
- Nutrient availability in the metastatic niche influences colonization efficiency; however, the metabolic heterogeneity of disseminated tumour cells can also reshape the local microenvironment 3 , 4 , 5.
- Loss of phosphoglycerate dehydrogenase (PHGDH), the rate-limiting enzyme in de novo serine biosynthesis, is observed in nearly 40% of PDACs, and renders these cells dependent on exogenous serine (exSer) 6.
