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H3K18 Lactylation in Degenerated Nucleus Pulposus Cells Suppresses CD248 Through Transcriptional and Post‐Translational Modifications to Promote Apoptosis and Extracellular Matrix Degradation

Source: Aging Cell • Published: 11 Nov 2026, 03:38

Summarized by Masters of Longevity from Aging Cell.

In degenerated human nucleus pulposus cells, H3K18 lactylation reduced CD248 and promoted degeneration.

H3K18 Lactylation in Degenerated Nucleus Pulposus Cells Suppresses CD248 Through Transcriptional and Post‐Translational Modifications to Promote Apoptosis and Extracellular Matrix Degradation
Key Takeaways
  • H3K18 lactylation is increased in human degenerated NP cells.
  • H3K18 lactylation was found to reduce CD248 transcription.
  • Reduced CD248 was associated with apoptosis and matrix degradation.
Read the full article at Aging Cell ↗

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