Summarized by Masters of Longevity from Lifespan.io.
A microbiome research piece previewing a mouse-focused study that probes a bacterial fatty acid’s potential to slow artery plaque and alter cholesterol metabolism.
Key Takeaways
- Oral administration of purified C15:0 cut plaque burden by about 50% and lowered total and LDL cholesterol in atherosclerosis‑prone mice.
- C15:0 directly bound and inhibited HMG‑CoA reductase, reducing hepatic cholesterol synthesis and raising LDL receptor activity.
- C15:0 levels and genes for its production were lower in humans with dyslipidemia and atherosclerotic cardiovascular disease compared to controls.
