Summarized by Masters of Longevity from Frontiers - Health.
GLP‑1 receptor agonists in metabolic dysfunction‑associated steatohepatitis: a planned systematic review and meta‑analysis protocol outlining trial synthesis methods.
Key Takeaways
- The review will include randomized controlled trials comparing GLP-1 receptor agonists with placebo or standard care in adults with MASH.
- Primary outcome is histological improvement defined as MASH resolution or fibrosis reduction, with secondary metabolic and safety endpoints.
- Trial Sequential Analysis and random-effects meta-analysis will be used to assess evidence robustness and control random errors.
