Summarized by Masters of Longevity from PR Newswire.
Preclinical mouse research links loss of the tumor suppressor gene TUSC2 to accelerated hippocampal aging and identifies sex-specific differences in cellular resilience.
Key Takeaways
- TUSC2 expression declined with age in 11 of 13 human brain regions and was further reduced in Alzheimer’s datasets.
- TUSC2 knockout mice showed mitochondrial dysfunction, impaired proteostasis, and accelerated molecular signs of hippocampal aging.
- Male TUSC2-deficient mice had greater mitochondrial and synaptic pathway disruption while females showed adaptive stress responses.
