Summarized by Masters of Longevity from Fight Aging!.
A newsletter synthesizing recent longevity research on muscle fat infiltration, cardiolipin-linked mitochondrial dysfunction, exercise effects on epigenetic aging, and heart regeneration advances.
Key Takeaways
- Myosteatosis increases with age independent of weight change and is more prevalent in women and some racial and ethnic groups.
- Reduced cardiolipin in mitochondria causally drove glycolytic-to-oxidative fiber shifts and muscle atrophy in mice and human tissue models.
- A yearlong remote exercise program slowed epigenetic aging by GrimAge2 and DNAmFitAge and linked methylation changes to cognitive measures.
