Summarized by Masters of Longevity from Frontiers - Health.
Evaluates how two lab-derived aging metrics predict postoperative mortality across hospitals and whether they add predictive value to clinical models.
Key Takeaways
- Each 1-SD increase in phenotypic age acceleration was associated with higher 540-day mortality (HR 1.34; 95% CI 1.03–1.75).
- The laboratory frailty index showed a borderline 540-day mortality association (HR 1.28; 95% CI 1.00–1.65) and predicted a 12-month death-or-incident-disease composite (RR 1.36; 95% CI 1.08–1.71).
- Adding phenotypic age acceleration and FI-Lab to a clinical model changed AUC modestly from 0.60 to 0.63 in external validation without consistent decision-curve net-benefit gains.
