Summarized by Masters of Longevity from Nature Aging.
Exercise-driven extracellular vesicles and their microRNA cargo are investigated as a mechanism linking physical activity to improved cartilage cell health; this article explains the study approach and implications for aging tissues.
Key Takeaways
- A 3-month aerobic exercise intervention increased microRNA-29 levels in circulating extracellular vesicles from older adults.
- Exercise-primed EVs de-repressed the KLOTHO promoter and restored youthful chondrocyte phenotypes in vitro.
- Intra-articular delivery of exercise-primed EVs improved cartilage health in aged mice, and miRNA-29 was necessary for effects.
