News summary

Development and Validation of a Risk Stratification Model for Mild Cognitive Impairment Among Older Adults with Possible Sarcopenia Integrating Traditional Chinese Medicine Constitution: A Multicenter Cross-Sectional Study

Source: Frontiers - Health • Published: 11 Oct 2026, 00:00

Summarized by Masters of Longevity from Frontiers - Health.

Presents a multicenter cross-sectional machine learning model that combines Traditional Chinese Medicine constitution and clinical indicators to estimate concurrent probable mild cognitive impairment risk in older adults with possible sarcopenia.

Development and Validation of a Risk Stratification Model for Mild Cognitive Impairment Among Older Adults with Possible Sarcopenia Integrating Traditional Chinese Medicine Constitution: A Multicenter Cross-Sectional Study
Key Takeaways
  • A seven-feature model retained education, sex, smartphone use, sleep quality, depressive symptoms, qi-deficiency, and damp-heat constitutions.
  • The multilayer perceptron achieved internal AUC 0.853 and external AUC 0.799 for classifying screening-defined probable MCI.
  • External validation showed modest calibration and limited transportability, indicating the need for prospective multicenter validation and recalibration.
Read the full article at Frontiers - Health ↗

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