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Deep and quantitative proteomic profiling of low-volume mouse serum in a cross-sectional analysis of aging

Source: Nature Aging • Published: 02 Nov 2026, 00:00

Summarized by Masters of Longevity from Nature Aging.

Nanoparticle enrichment plus DIA mass spectrometry profiled 3,992 proteins from 20 μl serum.

Deep and quantitative proteomic profiling of low-volume mouse serum in a cross-sectional analysis of aging
Key Takeaways
  • The workflow found 3,992 protein groups from 20 μl serum.
  • Age- and sex-specific circulating protein changes were reported.
  • Comparison with human data showed conserved age-associated proteins.
Read the full article at Nature Aging ↗

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