Summarized by Masters of Longevity from Nature - Main.
Perioperative ctDNA dynamics and pathological response are examined in a trial-style article assessing biomarkers and outcomes for resectable lung cancer.
Key Takeaways
- The Dato-DXd combination produced the highest pCR rate at 35.2% in the trial cohort.
- CtDNA clearance by neoadjuvant Cycle 3 Day 1 was 72.5% with the Dato-DXd arm.
- Pooled ctDNA clearance correlated with longer EFS versus non-clearance with HR 0.22.
