Summarized by Masters of Longevity from Nature - Main.
A short feature describing a lab study that maps how a cold-triggered metabolite network connects muscle to other tissues, with implications for ageing and protein quality control.
Key Takeaways
- Here we define a metabolite-driven, multi-tissue signalling system that links cold temperature to enhanced longevity and proteostasis in Caenorhabditis elegans.
- BH2 is produced in muscle and transported to distal tissues, including the intestine and neurons, where it is converted into BH4 by the salvage enzyme DHFR-1.
