Summarized by Masters of Longevity from Fight Aging!.
CircRNA expressing OCT4, SOX2, KLF4 rejuvenated late-passage MSCs without iPSC conversion.
Key Takeaways
- Circ-OSK delivery was transient and did not generate iPSCs.
- Treatment reduced senescence markers, DNA damage, and inflammatory signals.
- Rejuvenated MSCs retained identity and genome integrity with restored function.
