Summarized by Masters of Longevity from Fight Aging!.
Chronic inflammation and aging: a narrative review linking immune-driven processes to coordinated decline in bone and brain health, and implications for therapies.
Key Takeaways
- Chronic low-grade inflammation driven by senescent cells and SASP promotes both bone loss and neuroinflammation through shared cytokine signaling pathways.
- Age-related remodeling of bone endocrine signals, including decreased osteocalcin and increased sclerostin, may worsen brain Wnt/β-catenin signaling and cognitive vulnerability.
- Targeting upstream inflammaging mechanisms — such as senolytics, NLRP3 or cGAS-STING inhibitors, and microbiota interventions — requires dual-endpoint trials enriched for inflammaging biomarkers before clinical adoption.
