Summarized by Masters of Longevity from Nature - Biotechnology.
A review summarizes expanding CAR-T cell applications beyond cancer, covering autoimmune, infectious, senescence, and fibrotic targets and design evolution.
Key Takeaways
- CAR-T strategies are being repurposed to target pathogenic B cells in autoimmune diseases and induce durable immune remodeling.
- Preclinical and early clinical studies report CAR-T activity against senescent cells, infected cells, and fibrogenic cell populations.
- Multiple clinical trials testing CAR-T approaches for non-oncological indications have been initiated, with some interim positive results reported.
