Summarized by Masters of Longevity from Nature - Main.
Reports a myosin-targeting small molecule that selectively relaxes capillary pericytes to reverse capillary no-reflow and improve outcomes across heart and kidney reperfusion models.
Key Takeaways
- R(+)2501 is a myosin-specific vasodilator that rapidly restores capillary blood flow in reperfused animal models.
- Treatment with R(+)2501 reduced infarct size and markedly improved survival after acute myocardial ischemia in animals.
- R(+)2501 reversed renal capillary no-reflow after myocardial infarction and restored kidney function in animal studies.
