Summarized by Masters of Longevity from Fight Aging!.
Mouse and patient-aligned data show YAP1-TEAD–linked demethylation can produce HCC.
Key Takeaways
- YAP1-TEAD activation in hepatocytes was found to drive HCC.
- Widespread DNA demethylation was reported to activate multiple oncogenes.
- TET1 reduction was shown to attenuate epigenetic tumor formation.
