Summarized by Masters of Longevity from Nature Aging.
Brain DNA methylation and its links to genetic risk: a research article examining epigenetic patterns across postmortem brains and their relation to Alzheimer’s pathology.
Key Takeaways
- The study profiled DNA methylation at over 935,000 CpG sites in 1,250 prefrontal cortex samples and analyzed multiple AD neuropathologic measures.
- A total of 107 differentially methylated probes were associated with AD neuropathology, with 38 probes replicated in an independent cohort.
- DNA methylation was estimated to mediate 8.6% of the APOE genotype effect on Alzheimer's diagnosis, with P = 2 × 10⁻⁶.
