Summarized by Masters of Longevity from Lifespan.io.
A short popular-science article about a mouse-study investigation into how immune signaling between marrow fat and macrophages influences bone aging, and why blocking that pathway slowed deterioration.
Key Takeaways
- Macrophage cGAS–STING pathway activation increased with mouse age and correlated with more cytosolic DNA and cGAMP production.
- Macrophage-specific STING silencing between middle and old age preserved bone density and reduced marrow adipocyte numbers in mice.
- Marrow adipocytes secreted higher DPP4 with age, which engaged TLR4 to activate macrophage STING and increased CD38-associated NAD+ degradation in nearby cells.
