Summarized by Masters of Longevity from Nature - Main.
Survey of emerging genome editors that aim to insert large DNA segments and reprogram cells, assessing delivery hurdles and application trade-offs.
Key Takeaways
- PASTE-style approaches achieved roughly 50% liver correction in cynomolgus monkeys using lipid nanoparticles plus AAV delivery.
- CRISPR-associated transposases and other hybrid systems can target much larger DNA insertions but raise delivery and complexity challenges.
