News summary

Association of complete blood cell count-derived inflammatory biomarkers with the prevalence and mortality risk of osteoporosis: evidence from NHANES and an independent Chinese hospital-based case-control cohort

Source: Frontiers - Health • Published: 11 Oct 2026, 00:00

Summarized by Masters of Longevity from Frontiers - Health.

Routine blood-count inflammation markers and their links to osteoporosis outcomes — a population and hospital cohort study preview that highlights study scope and approach.

Association of complete blood cell count-derived inflammatory biomarkers with the prevalence and mortality risk of osteoporosis: evidence from NHANES and an independent Chinese hospital-based case-control cohort
Key Takeaways
  • In NHANES (n=16,539; 1,223 osteoporosis cases) NLR, MLR, NMLR, and SIRI were positively associated with all-cause mortality after multivariable adjustment and FDR correction.
  • CBC-derived biomarkers showed no significant association with osteoporosis prevalence or CVD mortality after multivariable adjustment and FDR correction.
  • An independent Chinese hospital case-control cohort (63 patients, 63 controls) found higher NLR, MLR, NMLR, and SIRI in osteoporosis patients, especially females.
Read the full article at Frontiers - Health ↗

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