Summarized by Masters of Longevity from Fight Aging!.
A review argues many benefits attributed to dietary methionine restriction actually stem from reduced cysteine, summarizing genetic and dietary experiments in worms and mice.
Key Takeaways
- Cysteine reduction alone extended lifespan and stress survival in Caenorhabditis elegans independently of methionine.
- CTH knockout mice on cysteine-free diets showed pro-metabolic and healthspan benefits while methionine-replete diets did not.
- Sustained ~70% cysteine reduction in aged CTH-deficient mice reprogrammed immunometabolic pathways and improved healthspan markers.
