Summarized by Masters of Longevity from Nature - Biotechnology.
Engineered multivalent aptamers enabled near-complete A-to-I editing in cells and mice.
Key Takeaways
- MARRS is reported to recruit endogenous ADAR1 p150 robustly.
- Editing efficiencies were up to 100% in vitro and 84% in vivo.
- Evidence is from engineered RNAs in cells and mouse models.
