Summarized by Masters of Longevity from Fight Aging!.
Researchers examined how different APOE alleles affect pericyte function and blood–brain barrier resilience, comparing allele-specific effects across mouse and human cell models.
Key Takeaways
- APOE2 knock-in mice showed higher pericyte markers and improved blood–brain barrier integrity compared with APOE3 and APOE4 mice.
- Isogenic human iPSC-derived APOE2 pericytes provided greater in vitro BBB integrity and resisted senescence more than APOE3 or APOE4 cells.
- APOE2 pericytes had distinct lipidomes with reduced phospholipids, increased triglycerides, lower lipid droplet accumulation, and upregulated lipid catabolism proteins.
