Summarized by Masters of Longevity from Frontiers - Health.
This mini-review invites readers into a conceptual reframing that treats liver inflammation as the downstream sign of systemic adipose failure, offering an upstream, adipose-focused lens for researchers and clinicians.
Key Takeaways
- Adipose inflammation and a reconfigured adipokine secretome produce selective insulin resistance and systemic metabolic inflexibility.
- Hepatic steatosis and steatohepatitis arise from failed peripheral lipid buffering and increased lipotoxic, immunometabolic burden on the liver.
