Summarized by Masters of Longevity from Nature Aging.
A retinoid-driven lipogenic program alters NK membrane mechanics and impairs cytotoxicity.
Key Takeaways
- Aging is linked to higher retinoid uptake in human NK cells.
- RA-activated SREBP1–ELOVL6 signaling was found to change membrane lipids.
- ELOVL6 inhibition was shown to improve mechanics and enhance antitumor activity.
