Tenoxicam-loaded bioglass/chitosan composites for bone tissue engineering: in vitro characterization, sustained drug release, and antimicrobial activity
Sol–gel Tenoxicam-loaded bioglass/chitosan composites (1–3 wt%) were characterized by FTIR, XRD, SEM and EDX, forming hydroxyapatite after SBF immersion, exhibiting porous microstructure, sustained zero-order Tenoxicam release for 33 days (highest at 3 wt%), and antibacterial activity versus Staphylococcus aureus, S. haemolyticus, Escherichia coli, and Klebsiella pneumoniae, supporting their potential for bone tissue engineering and post-surgical implants.
Why it matters33-day zero-order Tenoxicam release enables local anti-inflammatory therapy and reduces systemic dosing for post-surgical implants.