Self-destructing attenuated adjuvant Salmonella serves as a safe and potent live vaccine adjuvant
Engineered self-destructing attenuated Salmonella (SDAAS) strains incorporate programmed auxotrophy, lipid A and LPS modifications, and modified flagellin to create a safe, tunable live bacterial adjuvant. Lead strain φ712621 elicited robust TLR4/TLR5-mediated innate activation and antigen-specific IgG comparable to or exceeding alum, while showing self-limited growth and complete safety after parenteral and mucosal delivery in preclinical models.
Why it mattersSDAAS strain φ712621's strong TLR4/TLR5 activation and safety suggests vaccine developers should prioritize mucosal adjuvant testing.