Scientists reverse muscle aging in mice and discover a surprising catch
UCLA researchers report aged muscle stem cells accumulate NDRG1, slowing activation and repair; blocking NDRG1 restores regeneration in mice but reduces stem-cell resilience over time, indicating a survival trade-off (Science).
Why it mattersUCLA's NDRG1 finding implies NDRG1-targeting therapies must monitor long-term muscle stem-cell resilience.