Scientists reveal why a popular anti-aging compound may also fuel cancer
Researchers at Tokyo University of Science report that polyamines drive increased protein synthesis of the translation initiation factor eIF5A2, altering mRNA decoding distinct from eIF5A1. The mechanism helps explain why polyamines—linked to longevity benefits—are also frequently elevated in aggressive tumors, raising safety questions for polyamine-based supplements and therapies.
Why it mattersTokyo University of Science and Journal of Biological Chemistry link polyamines to eIF5A2; reassess supplements and trials for cancer-risk patients.
Entities Mentioned
Tokyo University of Science