Scientists engineer bacteria to eat cancer tumors from the inside out
Researchers at the University of Waterloo engineered Clostridium sporogenes with a quorum-sensing circuit that allows bacteria to colonize hypoxic tumor cores and activate oxygen-tolerant survival at tumor edges, demonstrating a programmed microbial approach to selectively consume tumors in a preclinical study published in ACS Synthetic Biology.
Why it mattersUniversity of Waterloo's engineered Clostridium sporogenes indicates prioritizing preclinical safety and delivery optimization immediately.