Scientists discover the switch that revives exhausted cancer-fighting T cells
Researchers at the Salk Institute built a high-resolution genetic atlas of CD8 T cell states and identified transcription factors that drive resilience versus exhaustion. Disabling two previously unknown genes restored tumor-killing activity of exhausted CD8 T cells while preserving long-term protective potential, according to a Nature paper.
Why it mattersSalk Institute mapped CD8 T cell states and found two genes whose loss restored tumor killing.
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Salk InstituteNature