Scientists discover hidden sugar layer behind psoriasis
Researchers identified a heparan sulfate glycocalyx on leukocytes that is shed to allow cells to exit blood and enter inflamed skin in psoriasis. The result shifts emphasis from blood-vessel changes to immune-cell surface remodeling and points to new ways to control tissue inflammation.
Why it mattersHeparan sulfate glycocalyx shedding controls leukocyte recruitment in psoriasis-like inflammation, enabling new anti-inflammatory target development.