Safety and biodistribution of intrathecal administration of mesenchymal stem cells (MSCs) and neurotrophin-releasing nanoparticles in a porcine CSF-guided delivery model for amyotrophic lateral sclerosis (ALS) drug discovery
Study reports short-term safety and biodistribution of intrathecally delivered mesenchymal stem cells combined with neurotrophin-releasing nanoparticles in a porcine model. MRI, CSF profiling, blood tests and histology found no adverse systemic effects and MSCs accumulated near spinal cord and brain.
Why it mattersMRI, CSF profiling and histology confirmed short-term safety after intrathecal MSC+NT injection in pigs, enabling ALS efficacy studies.