Relationships Between an Aged Oral Microbiome and Harms Done by Senescent Cells
Open-access review links age-associated oral microbiome changes to senescent cell SASP and systemic inflammation. Authors outline mechanisms by which periodontal dysbiosis could exacerbate cardiovascular and neurodegenerative disease, note inconsistent effect sizes, and discuss SASP-targeted intervention strategies.
Why it mattersOral microbiome–driven SASP activation suggests prioritizing periodontal screening to reduce systemic inflammation in trials.